MAP3K14 Back

mitogen-activated protein kinase kinase kinase 14

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NCBI Description of MAP3K14
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP3K14 is highly significantly mutated in
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MAP3K14 is significantly mutated in
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MAP3K14 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAP3K14