MAP3K13 Back

mitogen-activated protein kinase kinase kinase 13

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NCBI Description of MAP3K13

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MAP3K13 is highly significantly mutated in
MAP3K13 is significantly mutated in
MAP3K13 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MAP3K13