MAP3K11 Back

mitogen-activated protein kinase kinase kinase 11

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NCBI Description of MAP3K11

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP3K11 is highly significantly mutated in
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MAP3K11 is significantly mutated in
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MAP3K11 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MAP3K11