MAP3K10 Back

mitogen-activated protein kinase kinase kinase 10

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NCBI Description of MAP3K10
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP3K10 is highly significantly mutated in
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MAP3K10 is significantly mutated in
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MAP3K10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAP3K10