MAP2K3 Back

mitogen-activated protein kinase kinase 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MAP2K3
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Community Annotation of MAP2K3 Add / Edit MAP2K3: Annotations

No community annotations yet for MAP2K3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP2K3 is highly significantly mutated in
(none)
MAP2K3 is significantly mutated in
(none)
MAP2K3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAP2K3