MANBA Back

mannosidase, beta A, lysosomal

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MANBA
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.

Community Annotation of MANBA Add / Edit MANBA: Annotations

No community annotations yet for MANBA.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MANBA is highly significantly mutated in
(none)
MANBA is significantly mutated in
(none)
MANBA is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MANBA