mannosidase, beta A, lysosomal

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NCBI Description of MANBA

This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.

Community Annotation of MANBA Add / Edit MANBA: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MANBA is highly significantly mutated in
MANBA is significantly mutated in
MANBA is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MANBA