MAN2A1 Back

mannosidase, alpha, class 2A, member 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MAN2A1
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.

Community Annotation of MAN2A1 Add / Edit MAN2A1: Annotations

No community annotations yet for MAN2A1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAN2A1 is highly significantly mutated in
(none)
MAN2A1 is significantly mutated in
(none)
MAN2A1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAN2A1