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mucosa associated lymphoid tissue lymphoma translocation gene 1

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NCBI Description of MALT1
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of MALT1 Add / Edit MALT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MALT1 is highly significantly mutated in
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MALT1 is significantly mutated in
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MALT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MALT1