MAL2 Back

mal, T-cell differentiation protein 2

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NCBI Description of MAL2
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAL2 is highly significantly mutated in
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MAL2 is significantly mutated in
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MAL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAL2