MAL2 Back

mal, T-cell differentiation protein 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MAL2

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.

Community Annotation of MAL2 Add / Edit MAL2: Annotations

No community annotations yet for MAL2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MAL2 is highly significantly mutated in
MAL2 is significantly mutated in
MAL2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MAL2