MAGEB3 Back

melanoma antigen family B, 3

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NCBI Description of MAGEB3

This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAGEB3 is highly significantly mutated in
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MAGEB3 is significantly mutated in
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MAGEB3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MAGEB3