MAF1 Back

MAF1 homolog (S. cerevisiae)

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NCBI Description of MAF1

This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.

Community Annotation of MAF1 Add / Edit MAF1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAF1 is highly significantly mutated in
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MAF1 is significantly mutated in
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MAF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MAF1