MAD1L1 Back

MAD1 mitotic arrest deficient-like 1 (yeast)

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NCBI Description of MAD1L1
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.

Community Annotation of MAD1L1 Add / Edit MAD1L1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAD1L1 is highly significantly mutated in
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MAD1L1 is significantly mutated in
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MAD1L1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAD1L1