LZTS1 Back

leucine zipper, putative tumor suppressor 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LZTS1

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of LZTS1 Add / Edit LZTS1: Annotations

No community annotations yet for LZTS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LZTS1 is highly significantly mutated in
LZTS1 is significantly mutated in
LZTS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LZTS1