LUZP6 Back

leucine zipper protein 6

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NCBI Description of LUZP6

A bi-cistronic transcript encodes the products of both the myotrophin and leucine zipper protein 6 genes, which are located on chromosome 7. A cryptic ORF at the 3' end of the myotrophin transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS ID represents a 58 aa tumor antigen that is translated from a cryptic ORF at the 3' end of the bicistronic myotrophin transcript. It uses a non-AUG (AUU) translational start codon, as indicated by experimental evidence in PMID:16982933.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LUZP6 is highly significantly mutated in
LUZP6 is significantly mutated in
LUZP6 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LUZP6