LTBP4 Back

latent transforming growth factor beta binding protein 4

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NCBI Description of LTBP4
The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of LTBP4 Add / Edit LTBP4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LTBP4 is highly significantly mutated in
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LTBP4 is significantly mutated in
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LTBP4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LTBP4