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latent transforming growth factor beta binding protein 2

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NCBI Description of LTBP2
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.

Community Annotation of LTBP2 Add / Edit LTBP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LTBP2 is highly significantly mutated in
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LTBP2 is significantly mutated in
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LTBP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LTBP2