LTBP1 Back

latent transforming growth factor beta binding protein 1

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NCBI Description of LTBP1
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of LTBP1 Add / Edit LTBP1: Annotations

No community annotations yet for LTBP1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LTBP1 is highly significantly mutated in
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LTBP1 is significantly mutated in
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LTBP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LTBP1