LSS Back

lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LSS
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of LSS Add / Edit LSS: Annotations

No community annotations yet for LSS.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LSS is highly significantly mutated in
(none)
LSS is significantly mutated in
(none)
LSS is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LSS