LRTOMT Back

leucine rich transmembrane and 0-methyltransferase domain containing

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NCBI Description of LRTOMT
This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene.

Community Annotation of LRTOMT Add / Edit LRTOMT: Annotations

No community annotations yet for LRTOMT.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LRTOMT is highly significantly mutated in
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LRTOMT is significantly mutated in
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LRTOMT is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LRTOMT