LRSAM1 Back

leucine rich repeat and sterile alpha motif containing 1

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NCBI Description of LRSAM1
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LRSAM1 is highly significantly mutated in
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LRSAM1 is significantly mutated in
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LRSAM1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LRSAM1