leucine rich repeat and sterile alpha motif containing 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LRSAM1

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

Community Annotation of LRSAM1 Add / Edit LRSAM1: Annotations

No community annotations yet for LRSAM1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LRSAM1 is highly significantly mutated in
LRSAM1 is significantly mutated in
LRSAM1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LRSAM1