LRRN2 Back

leucine rich repeat neuronal 2

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NCBI Description of LRRN2
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Community Annotation of LRRN2 Add / Edit LRRN2: Annotations

No community annotations yet for LRRN2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LRRN2 is highly significantly mutated in
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LRRN2 is significantly mutated in
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LRRN2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LRRN2