LRRC2 Back

leucine rich repeat containing 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LRRC2

This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of LRRC2 Add / Edit LRRC2: Annotations

No community annotations yet for LRRC2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LRRC2 is highly significantly mutated in
LRRC2 is significantly mutated in
LRRC2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LRRC2