LRP5 Back

low density lipoprotein receptor-related protein 5

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NCBI Description of LRP5
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

Community Annotation of LRP5 Add / Edit LRP5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LRP5 is highly significantly mutated in
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LRP5 is significantly mutated in
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LRP5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LRP5