LRCH2 Back

leucine-rich repeats and calponin homology (CH) domain containing 2

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NCBI Description of LRCH2
This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants.

Community Annotation of LRCH2 Add / Edit LRCH2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LRCH2 is highly significantly mutated in
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LRCH2 is significantly mutated in
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LRCH2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LRCH2