lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)

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NCBI Description of LRAT

The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.

Community Annotation of LRAT Add / Edit LRAT: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LRAT is highly significantly mutated in
LRAT is significantly mutated in
LRAT is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LRAT