LPA Back

lipoprotein, Lp(a)

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NCBI Description of LPA

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. Sequence Note: This gene is highly polymorphic in length and number of exons due to variation in the number of kringle IV-2 repeats which vary from 2-43 copies among individuals. This RefSeq record was created from the reference genome assembly based on the exon representation found in DQ452068.1 whose sequence is consistent with the reference genome sequence, and includes 15 copies of the kringle IV-2 repeats.

Community Annotation of LPA Add / Edit LPA: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LPA is highly significantly mutated in
LPA is significantly mutated in
LPA is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LPA