LOX Back

lysyl oxidase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LOX
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of LOX Add / Edit LOX: Annotations

No community annotations yet for LOX.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LOX is highly significantly mutated in
(none)
LOX is significantly mutated in
(none)
LOX is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LOX