LMX1A Back

LIM homeobox transcription factor 1, alpha

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NCBI Description of LMX1A
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LMX1A is highly significantly mutated in
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LMX1A is significantly mutated in
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LMX1A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LMX1A