LMO2 Back

LIM domain only 2 (rhombotin-like 1)

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NCBI Description of LMO2
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of LMO2 Add / Edit LMO2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LMO2 is highly significantly mutated in
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LMO2 is significantly mutated in
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LMO2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LMO2