LLGL2 Back

lethal giant larvae homolog 2 (Drosophila)

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NCBI Description of LLGL2
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of LLGL2 Add / Edit LLGL2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LLGL2 is highly significantly mutated in
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LLGL2 is significantly mutated in
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LLGL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LLGL2