LIPT1 Back

lipoyltransferase 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LIPT1

The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene.

Community Annotation of LIPT1 Add / Edit LIPT1: Annotations

No community annotations yet for LIPT1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LIPT1 is highly significantly mutated in
LIPT1 is significantly mutated in
LIPT1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LIPT1