LIMS1 Back

LIM and senescent cell antigen-like domains 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LIMS1

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Community Annotation of LIMS1 Add / Edit LIMS1: Annotations

No community annotations yet for LIMS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LIMS1 is highly significantly mutated in
LIMS1 is significantly mutated in
LIMS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LIMS1