LILRA5 Back

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5

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NCBI Description of LILRA5
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LILRA5 is highly significantly mutated in
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LILRA5 is significantly mutated in
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LILRA5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LILRA5