LIG3 Back

ligase III, DNA, ATP-dependent

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NCBI Description of LIG3
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of LIG3 Add / Edit LIG3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LIG3 is highly significantly mutated in
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LIG3 is significantly mutated in
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LIG3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LIG3