LIG1 Back

ligase I, DNA, ATP-dependent

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NCBI Description of LIG1
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

Community Annotation of LIG1 Add / Edit LIG1: Annotations

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Sort mutations by: Tumor type  Mutation type  Position  
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LIG1 is highly significantly mutated in
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LIG1 is significantly mutated in
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LIG1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LIG1