LIAS Back

lipoic acid synthetase

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NCBI Description of LIAS
The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

Community Annotation of LIAS Add / Edit LIAS: Annotations

No community annotations yet for LIAS.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LIAS is highly significantly mutated in
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LIAS is significantly mutated in
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LIAS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LIAS