LHX4 Back

LIM homeobox 4

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NCBI Description of LHX4

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LHX4 is highly significantly mutated in
LHX4 is significantly mutated in
LHX4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LHX4