LHX3 Back

LIM homeobox 3

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NCBI Description of LHX3

This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LHX3 is highly significantly mutated in
LHX3 is significantly mutated in
LHX3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LHX3