lipoma HMGIC fusion partner-like 5

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NCBI Description of LHFPL5

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LHFPL5 is highly significantly mutated in
LHFPL5 is significantly mutated in
LHFPL5 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LHFPL5