LHFPL2 Back

lipoma HMGIC fusion partner-like 2

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NCBI Description of LHFPL2

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LHFPL2 is highly significantly mutated in
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LHFPL2 is significantly mutated in
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LHFPL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for LHFPL2