LHCGR Back

luteinizing hormone/choriogonadotropin receptor

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LHCGR
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.

Community Annotation of LHCGR Add / Edit LHCGR: Annotations

No community annotations yet for LHCGR.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LHCGR is highly significantly mutated in
(none)
LHCGR is significantly mutated in
(none)
LHCGR is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LHCGR