LGR4 Back

leucine-rich repeat-containing G protein-coupled receptor 4

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NCBI Description of LGR4

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008].

Community Annotation of LGR4 Add / Edit LGR4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


LGR4 is highly significantly mutated in
LGR4 is significantly mutated in
LGR4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for LGR4