LEMD3 Back

LEM domain containing 3

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NCBI Description of LEMD3
This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Community Annotation of LEMD3 Add / Edit LEMD3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LEMD3 is highly significantly mutated in
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LEMD3 is significantly mutated in
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LEMD3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LEMD3