LEFTY1 Back

left-right determination factor 1

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NCBI Description of LEFTY1
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Community Annotation of LEFTY1 Add / Edit LEFTY1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LEFTY1 is highly significantly mutated in
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LEFTY1 is significantly mutated in
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LEFTY1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LEFTY1