LDOC1 Back

leucine zipper, down-regulated in cancer 1

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NCBI Description of LDOC1
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LDOC1 is highly significantly mutated in
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LDOC1 is significantly mutated in
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LDOC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LDOC1