LDHB Back

lactate dehydrogenase B

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NCBI Description of LDHB
This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Community Annotation of LDHB Add / Edit LDHB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LDHB is highly significantly mutated in
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LDHB is significantly mutated in
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LDHB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LDHB