LBR Back

lamin B receptor

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NCBI Description of LBR
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Community Annotation of LBR Add / Edit LBR: Annotations

No community annotations yet for LBR.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LBR is highly significantly mutated in
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LBR is significantly mutated in
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LBR is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LBR