LATS2 Back

LATS, large tumor suppressor, homolog 2 (Drosophila)

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NCBI Description of LATS2

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Community Annotation of LATS2 Add / Edit LATS2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LATS2 is highly significantly mutated in
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LATS2 is significantly mutated in
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LATS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for LATS2