LAIR2 Back

leukocyte-associated immunoglobulin-like receptor 2

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NCBI Description of LAIR2
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of LAIR2 Add / Edit LAIR2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LAIR2 is highly significantly mutated in
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LAIR2 is significantly mutated in
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LAIR2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LAIR2