LAGE3 Back

L antigen family, member 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of LAGE3
This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9.

Community Annotation of LAGE3 Add / Edit LAGE3: Annotations

No community annotations yet for LAGE3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

LAGE3 is highly significantly mutated in
(none)
LAGE3 is significantly mutated in
(none)
LAGE3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for LAGE3